The failure of many of the WTA's main protagonists will also have implications on the battle for places at the BNP Paribas WTA Finals Singapore presented by SC Global.
Prior to the tournament, much of the talk surrounded the race to secure the first place at the Finals. However, premature losses for both Sharapova and her nearest competitor at the top of the Road To Singapore leaderboard, Simona Halep, could now see the outcome of this particular contest roll over into the Asian swing.
Sharapova is already turning her attention to the season’s final chapter. "There’s not really time to think too much about defeats, because the next tournament is quite soon actually," she said. "It's only a couple of weeks, I believe, after the US Open. It's in Asia, so, you know, it's a very quick turnaround. Just got to get ready for that."
Also looking to put her US Open disappointment behind her is Petra Kvitova.
"You know, I have a little bit bigger expectation for myself to play in this tournament," Kvitova said after her third round loss to Aleksandra Krunic. "I really wanted to have a deeper run than I had few years ago.
"Still, it was the last Grand Slam of the year. We are still playing about Singapore. I will do whatever I can to qualify for that. I mean, I will try to be on the high spot in the end of the season."
With Jelena Jankovic, Sara Errani, Caroline Wozniacki and several other players currently outside the qualification berths still alive and kicking in New York, competition on the leaderboard is likely to further intensify as the season enters its home straight.
Click here for the full Road To Singapore singles leaderboard.